Breathe’N’Roll™ is informed by many years of research on respiratory sensory pathways and the chemosensory sensitivity of the nasal cavity. The work of Dr. Naum Goldstein and other authors on the role of reactive oxygen species in ambient air and on nasal chemoreception informs a general-wellness hypothesis: in nature, a brief local stimulus may occur when naturally occurring active forms of oxygen contact the nasal mucosa.
Such contact is typically accompanied by small physicochemical changes (e.g., the release of O₂) that may be detected by receptor structures in the nasal cavity. This short, local signal may gently engage the body’s normal sensory mechanisms and may support subjective feelings of clarity, calm, and stress resilience. Individual experiences vary.
This is not a medical claim but a science-based concept for a general wellness product. The product is intended for local use only and is not intended to have systemic effects.
Which receptors are relevant
Several sensory systems in the nasal cavity may participate in the perception of brief local stimuli:
Chemosensory endings of the trigeminal nerve (V) — sensitive to local physicochemical changes on the mucosa and involved in reflex pathways.
Olfactory system — the olfactory mucosa sends signals to the olfactory bulb, where initial processing of odor information occurs.
Region of the vomeronasal organ (VNO) — in humans, its presence and functional significance are debated in the literature; in some cases this region may participate in chemosensory detection of specific stimuli.
We view these structures as potential “receivers” of a brief local sensory signal.
Hypothetical pathway for Breathe’N’Roll™
Why H₂O₂ (scientific linkage). In tissues, one active form of oxygen—superoxide—typically and rapidly converts to hydrogen peroxide (H₂O₂), which then breaks down into water and oxygen. Therefore, the product uses a microdose of H₂O₂ (<0.001%) as a controlled, short-acting local model of such a natural stimulus: at this trace concentration H₂O₂ is generally neutralized by mucosal enzymes (catalase/peroxidases).
* Goldstein N. Reactive oxygen species as essential components of ambient air. Biochemistry (Moscow). 2002;67(2):161–170. Read full study.
** Oboti L, Peretto P. How neurogenesis finds its place in a hardwired sensory system. Front Neurosci. 2014;8:102. Read full study.
*** Smith TD, Bhatnagar KP. Histological definition of the vomeronasal organ in humans and chimpanzees, with a comparison to other primates. Anat Rec. 2002;267(2):166–176. Read full study.
Hydrogen Peroxide Pathway
Steps (hypothesis):
1. The microdose is applied locally to the nasal cavity with an applicator.
2. Rapid breakdown: on the mucosal surface, H₂O₂ typically breaks down into H₂O and O₂ with the help of natural enzymes.
3. Brief local stimulus: this breakdown may be accompanied by a short-lived local physicochemical impulse.
4. Receptor engagement: the impulse may be noticed by receptor structures in the nasal cavity (see section above), after which natural sensory signaling may be initiated.
5. Natural body responses: such signaling may gently engage the body’s normal sensory pathways, supporting subjective feelings of clarity, calm, and a sense of stress resilience. Individual experiences vary.
* Goldstein N, Arshavskaya TV. Is atmospheric superoxide vitally necessary? Accelerated death of animals in a quasi neutral electric atmosphere. Z Naturforsch C. 1997;52(5–6):396–404. Read full study.
** Bhatnagar KP, Smith TD. The human vomeronasal organ. Part V. An interpretation of its discovery by Ruysch, Jacobson, or Kölliker, with an English translation of Kölliker (1877). Anat Rec B New Anat. 2003;270(1):4–15. Read full study.
Safety and Innovation
Sources of inspiration
Research by Dr. Goldstein on reactive oxygen species in air and on nasal chemosensitivity informed the development of a careful, local sensory concept. We translated these ideas into product design without medicinal claims and with a focus on low dose and locality.
What we do not claim
We do not claim effects on diseases, cognitive disorders, or “brain health.”
We do not claim systemic or long-lasting effects.
Mentions of the VNO, trigeminal nerve, and olfactory bulb are provided as scientific background; their possible role in relation to the product is hypothetical.
Disclaimer: Breathe’N’Roll™ is a general wellness product. It is not a drug. Not intended to diagnose, treat, cure, or prevent any disease. For local use only; not intended to have systemic effects. These statements have not been evaluated by the FDA.